子宮內膜接受性基因分析(Endometrial Recepivity Analysis-ERA)真的能提供個別化的胚胎移植精準預判嗎?

版主: 克莉絲

回覆文章
寶醫師
文章: 297
註冊時間: 2013年 10月 15日, 07:38

2019年 1月 6日, 12:40

基因微陣列技術拓(genomic microarray)拓寬了對許多研究領域的洞察力,使科學家能夠在快速有效的實驗中分析許多基因的表達,旨在將這些研究結果轉化為臨床應用。在生殖醫學,研究人員利用基因微陣列來增加對子宮內膜容受性(胚胎著床窗)中涉及的分子機制的理解,以及可能的治療性轉譯是如何可行的。在過去的多年中,多項研究的重點是人類子宮內膜在不同生理和病理方面的基因表現,這些研究已經產生了大量關於調節和失調的信息植入窗(WOI),使基因在可育,低生育和難治的條件下研究關鍵分子/子宮內膜容受性的機制仍有待闡明。

復發或重複植入失敗(RIF)可能是毀滅性的。一些患者接受三輪或更多輪IVF治療,一切似乎都順利進行:取出時卵數量多,受精率高,胚胎看起來健康,質量高,子宮內膜看起來很好,轉移順利,但懷孕永遠不會持續發生。

對於試圖追查原因的生育專家來說,這也是一個棘手和令人沮喪的情況。患者需要答案,醫生想要幫助。令人高興的是,新的測試和技術正在不斷發展,以幫助生殖專家提供一些這些答案,並幫助患者找到正確的懷孕途徑。 ERA測試是這些新發展之一,為應對植入失敗的患者提供新信息和新希望

ERA測試如何運作?
且需要在周期中非常特定的時間獲得的子宮內膜樣本。
使用補充雌激素和黃體酮也可以使用生育藥物來製備子宮內膜。黃體酮開始的那天是第零天,並且在那之後五天進行測試。以稱為子宮內膜活組織檢查的程序採集組織樣本。將細導管穿過子宮頸插入子宮腔,並使用導管中的柱塞產生抽吸並將微小的子宮內膜襯裡樣品吸入導管。許多女性發現這部分過程非常不舒服,但這是一個非常快速的過程。然後使用下一代測序技術將樣品送至實驗室進行分析。結果可在大約三週內獲得。如果結果返回組織為“不接受”,那麼應該更早或更晚地重複測試,直到確定最佳時間。一旦確定了患者的接受窗口,就可以使用個性化胚胎移植(pET)定時植入胚胎。

當子宮內膜襯裡是接受性的時,子宮內膜細胞的遺傳物質具有獨特的“表達”,這意味著它們可能或多或少地產生某些類型的RNA。研究人員分析了每個樣本中236個基因的表達,並建立了超過12,000個子宮內膜組織樣本的數據庫,以查看在周期的不同時間產生的RNA水平。然後,他們使用先進的計算機算法尋找模式,直到他們可以根據其特定的表達譜將樣本可靠地分類為“接受”或“不接受”。該測試具有高度可重複性,這意味著當樣品在循環的同一時間進行測試但間隔數月時,結果保持不變。使用ERA,醫生可以確定女性的“植入窗口”是否在預期時發生,或者是否需要移動轉移日期以確保胚胎和子宮內膜之間的最佳“同步”。

ERA的若干爭議測試?
基因微陣列技術提功大量訊息,然而所有發揮生理功能的是在蛋白質層次,換言之自DNA轉錄到RNA甚至轉譯到蛋白質的真實大段差距,有些基因微陣列呈現的訊號部一定要在蛋白質層次影響在子宮內膜容受性分析經過如此多的壓力,物力和金錢投資,重複植入失敗造成的失望和痛苦往往是嚴重的。如果您或您關心的人一直在努力解決無法解釋的IVF週期失敗,請考慮向您的生育專家詢問ERA。它為您提供了一個新的數據點,信息就是力量。有時一天的轉變就是在重複植入失敗後看到成功所需要的。
花費要有意義, ERA的成本約為850美元,除了藥物和醫療回診次數增加的成本之外,對大多數人而言也是影響。所需的額外成本和時間是在更多IVF週期中為什麼不預先使用測試的此技術。Cost(花費)是否無謂增加都是醫病間的考慮,若加上三代試管(PGS)的花費更顯驚人。若有了ERA的先行檢查,胚胎端未測試就無法提供全面的訊息,如精準的著床點確植入了染色體異常的胚胎(一代二代試管),若有更簡易的檢查或ERA的cost down(低價化),有些患者應該考慮像ERA一樣進行更多的測試。 這個額外費用可以是一個IVF週期提前成功的和多個失敗週期之間的差異。醫師間仍很多人不認同ERA,認為精準度,真實性及患者的花費產生而對ERA的不以為然。

結論:
在冷凍胚胎移植之前的模擬週期中進行ERA測試似乎不一定全面能改善良好預後患者的持續妊娠率。 需要進一步的大型前瞻性研究來闡明ERA檢測在良好預後患者和復發性植入失敗患者中的作用。

本文參考
1. Malizia BA, Hacker MR, Penzias AS. Cumulative live-birth rates after in vitro fertilization. N Engl J Med 2009;360:236-43.
2. Simon A, Laufer N. Repeated implantation failure: clinical approach. Fertil Steril 2012;97:1039-43
3. Ruiz-Alonso M, Blesa D, Díaz-Gimeno P, Gomez E, Fernandez-Sanchez M, Carranza F, et al. The endometrial receptivity array for diagnosis and personalized embryo transfer as a treatment for patients with repeated implantation failure. Fertil Steril 2013;100:818–24.
4. Hertig AT, Rock J, Adams EC. A description of 34 human ova within the first 17 days of development. Devel Dynam 1956;98:435–93.
5. Navot D, Scott RT, Droesch K, Veeck LL, Liu H-C, Rosenwaks Z. The window of embryo transfer and the efficiency of human conception in vitro. Fertil Steril 1991;55:114–8.
6. Wilcox AJ, Baird DD, Weinberg CR. Time of implantation of the conceptus and loss of pregnancy. N Engl J Med 1999;340:1796–9.
7. Díaz-Gimeno P Horcajadas JA, Martínez-Conejero JA, Esteban FJ, Alamá P, Pellicer A, Simón C. A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature. Fertil Steril 2011;95:50-60, 60.e1-15
8. Ruiz-Alonso M, Blesa D, Simon C. The genomics of the human endometrium. Biochim Biophys Acta 2012;1822:1931–42.
9. Ruiz-Alonso M, Galindo N, Pellicer A, Simon C. What a difference two days make: ‘‘personalized’’ embryo transfer (pET) paradigm: a case report and pilot study. Hum Reprod 2014;29:1244–7.
10. Simon C, Vladimirov IK, Castillon Cortes G, Ortega I, Cabanillas S, Vidal C, et al. Prospective, randomized study of the endometrial receptivity analysis (ERA) test in the infertility work-up to guide personalized embryo transfer versus fresh transfer or deferred embryo transfer. Fertil Steril 2016; 106 (supplement): e46-7.
11.Human Reproduction Update, Vol.13, No.1 pp. 77–86, 2007
12.J Assist Reprod Genet. 2018 Jul;35(7):1301-1305
ggaoiuaqw870
文章: 1509
註冊時間: 2022年 8月 25日, 09:08

2022年 9月 21日, 16:58

Nike
Air Jordan 30
Jordans 12
Pandora Rings Official Site
Nikes Shoes
Cheap Jordans
Nike Shoes For Men
Pandora Charms
Air Jordan 18
Jordan 26
Jordan 13
Jordan Retro
Lebron James Sneakers
Jordan 13
Nike Air Max 95 Essential
Pandora Jewelry Charms
Cheap Womens Nikes
Jordan 33
Air Max Shoes
Pandora Rings
Nike Air Zoom
Jordan 31
Nike Running Shoes For Men
Pandora Jewelry 70 Off Clearance
Nike Free Rn 2019
Jordan 23
Pandora Bracelet Charms
Jordan Shoes
Air Jordan 32
Custom Jerseys Canada
Nike Black Friday Deals
Pandora Bracelet
Air Force 1
Air Jordan
Adidas Shoes For Men
Jordan 15
Nike Outlet
Jordan 21
Louboutin Shoes
Nike Air Max Women
Pandora Jewelry Charms
Nike Air Foamposite
Nike Canada
Nike Shoes Wholesale
Cheap MLB Jerseys
Nike Huaraches
Air Jordan 33
Jordans 22
Red Bottoms
Pandora Jewelry Black Friday
Nike Outlet Store
Infant Jordans
Cheap Jordan 1
Air Jordan 1 Retro
Nike Shoes
Cheap Wholesale Nike Shoes Free Shipping
Christian Louboutin
Nikes Shoes
Air Max 97
Huaraches
Nike Clearance Store
Nike Wholesale
Nike Outlet Store
Michael Jordan Shoes
Nike Women's Shoes
Jordan Retro 4
Jordan 35
New Jordans
Wholesale Nike Shoes
Air Max Shoes
Cheap Jordans
Nike Outlet
Jordan 20
Nike Factory Outlet
Pandora Jewelry
Nike Air Max 270
Nike Shoes Outlet Store Online Shopping
Jordan 19
Ice Jerseys
NHL Store
Nike Blazers
NFL Shop Canada
Nike Factory
Jordans 6
Cheap Adidas Shoes
Jordan 24
Nike Free rn
Jordans 34
Wholesale Cheap Jordans
Jordan AJ 1
Nike Shoes
Air Max 2019
Nike SB Dunk
Off White Nike
Wholesale Adidas
Wholesale Adidas Sneakers
Cheap Nike Shoes
Nike Air Max 270
Pandora Jewelry
Nike Jordan 1 High
Jordan 16
Jordan 11 Concord
Air Force Ones Nike
Pandora Official Site
Nike Outlet
Pandora Jewelry Outlet
Pandora Jewelry
Jordan 2
What The Jordan 5
Wholesale Jordans
NMD
Pandora Bracelet
Air Jordan 27
Adidas Yeezy Official Website
Nike Outlet Store
Nike Air Force 1 High
Jordan 28
Wholesale Shoes And Clothing
Pandora
Air Jordan 17
Dior Jordans
Jordan Retro 11 Low
Huaraches
Adidas Store
Pandora Jewelry Official Site
Nike Outlet Store Online Shopping
Kids Jordans
Pandora Charm
Nike React
Nike Outlet
Jordan 11
Nike Roshe Men
Nike Air Jordan
Jordan 25
Nike Sneakers
Nike Shoes Canada
Jordan 14
MLB Shop
Air Jordan 11 Retro
Nike Hyperdunk
Air Force 1 Women
Nike Shoes
Nike Air Force
Air Max
Jordan 12 Retro
Pandora Jewelry Outlet
Yeezy Boost 350 V2
Pandora Jewelry
Nike Shoes
Nike Running Shoes For Women
Nike Cortez
Nike
Cheap Jordans
Jordan 33
Custom Jerseys
Pandora
Jordan 12
Nike Zoom
Air Max 720
Air Jordan 29
ggaoiuaqw870
文章: 1509
註冊時間: 2022年 8月 25日, 09:08

2022年 9月 22日, 19:31

Pandora
Pandora Bracelet
Moncler Jackets
Nike Outlet
Pandora Charms
Pandora Charms
Balenciaga
Nike Store
Air Max
Pandora Charms
Adidas Website
Moncler Coat Men
Moncler
Pandora Jewelry
Nike Store UK
Moncler Jackets
Jordan 1 Low
Moncler Jackets
Asics Sneakers For Men
Goyard Bags Outlet
Ferragamo
Cheap Moncler Coats
Asics Outlet Store Online
Air Jordan 1 Retro
Pandora Jewelry Official Site
Jordans Sneakers
Balenciaga Triple S
Asics Shoes
Adidas Sneakers
Goyard Handbags
Cheap Moncler
Moncler Jackets
Pandora Charms
Pandora Outlet
Nike
Nike 270 Air Max
Pandora Charms
Pandora Jewelry
Nike Air Jordan 1
Air Jordan 1 Mid
Pandora Charms
Nike Snkrs Canada
Jordan 1 Retro
Pandora Bracelet Charms
Balenciaga Sneakers
Adidas Shoes Men
Pandora
Nike Outlet Store
Pandora Charms
Pandora Bracelets
Jordan 1 Lows
Shoes Ferragamo
Nike Shoes Women
Pandora Jewellery
Pandora Charms Sale Clearance
Pandora Official Site
Balenciaga
Nike Outlet
Adidas Store
Pandora Jewelry Official Site
Pandora Jewellery
Nike Running Shoes Sale
Dior Jordan 1
Pandora Jewelry 70% Off Clearance
Basketball Shoes
Pandora Outlet
Asics Kayano
Pandora Charms
Pandora Jewelry
Pandora Outlet
Air Jordan 1
Pandora
Adidas Running Shoes Women
Jordan 5
New Nike Shoes
Pandora Website
Salvatore Ferragamo
Pandora
Pandora Bracelets
Men's Nike Shoes
Puma Shoes
Pandora Jewelry
Nike Shoes
Pandora Charms
Pandora Jewelry
Adidas Shoes
Balenciaga Shoes
Pandora Outlet
Pandora Ring
Pandora
Pandora Jewelry
Pandora Jewelry
Moncler Sale
Balenciaga Shoes
Nike Shoes Men
Jordan 1s
Asics Running Shoes
Pandora Jewelry
Moncler Jacket For Men
Cheap Nike Shoes
Cheap Adidas Shoes
Women Nike Sneakers
Air Max 97
Pandora Charms
Adidas Shoes For Women
Wholesale Jordan Shoes From China
Pandora Jewelry Official Site
Nike Air Jordans 1
Pandora Charms
Asics Shoes
Pandora Jewelry Official Site
Ferragamo Belts
Moncler Outlet
Nike
Pandora
Jordan 1
Jordan One
Pandora Jewelry
Nike Shoes For Women
Adidas Sale
Pandora Outlet
Nike Air Max 720
Pandora Jewelry
Adidas Trainers
Pandora Charms
Moncler Coats
NMD R1
Air Jordan 1 Retro
Pandora Store
Air Jordan Shoes
Nike Air Jordans
Jordan 1 Retro High
Pandora Ring
Balenciaga Sneakers Outlet
Jordan 1 Retro
Discount Jordan Shoes Wholesale
Wholesale Retro Jordans
Adidas Canada
Asics
Men Nike Sneakers
Yeezy
Pandora Jewelry Official Site
Jordan 1 Retro
Pandora Charms
Pandora Jewelry
Cheap Jordan Shoes
Pandora Charms
Nike Canada
Yeezy
Ferragamo Belt
Air Jordan Sneakers
New Nike Shoes
Nike Store
Pandora Bracelets Clearance
Pandora Bracelet
Pandora Jewelry
Nike Canada
ggaoiuaqw870
文章: 1509
註冊時間: 2022年 8月 25日, 09:08

2022年 9月 29日, 15:37

Nike Air Max 90
Nike Cortez Women
Nike Air Zoom
Nike Free Rn 2019
Pandora Necklaces
Jordan 12s
Air Jordans
Nike Outlet
Jordan 13 Retro
Jordan Retro 11
Yeezys
Lebron James Shoes
Nike Jordan
Valentino
Nike Epic React
Ferragamo Belts
Vans Outlet
Red Bottoms
Nike Running Shoes For Men
Nike Air Max 95 Essential
Ferragamo
Nike Outlet Store Online Shopping
Nike Clearance Sale
Yeezy Boost
Nike Factory Store
Adidas Yeezy
Nike Cortez Women
Nike Sneakers For Women
Red Bottom Shoes
Yeezy
Pandora
Air Force Ones
Nike Basketball Shoes
Air Jordan 1 High
Nike Prestos
Air Force One Nike
Pandora Rings
Nike Outlet Store
Nike Shoes
Pandora Charms
Pandora UK
Jordan 32
Air Jordan 8
Jordans Sneakers
Jordan Retro 11
Red Bottom Heels
Pandora Charms
Nike Air Mag
Nike Air Force 1 Men
Jordan Shoes For Men
Pandora Charms Jewelry
Louboutin Shoes
New Jordans
Pandora Bracelet
Nike Factory
Jordan AJ 1 Mid
Nike Free Run
Yeezys Boost 350 V2
Christian Louboutin UK
Jordan 4
Nike Outlet Store Online
Fjallraven Kanken Backpack
Louboutin Heels
Ultra Boost
Moncler UK
Louboutin Outlet
Nike Outlet
Jordan Retro
Yeezy Shoes
Adidas NMD
Nike Sneakers For Men
Pandora Bracelets
Jordan 1
Nike Outlet Store Online
Nike Factory Store Online
Pandora Jewelry Official Site USA
Jordan Retro 4
Nike Clearance Store
Christian Louboutin Outlet
Nike Air Max 98
Pandora Earrings
Nike Outlet Store
Lebron 16
Nike Shoes
Nike Sneakers Sale
Air Max
Nike Outlet
Nike Clearance
Fjallraven Backpack
Nike Outlet Store
Basketball Shoes Nike
Jordan 7
Kyrie Irving Sneakers
Nike Running Shoes
Jordan 11 Gamma Blue
Nike Shoes
Nike Outlet Online
Air Max 98
Nike Air Max 270
Adidas NMD
Jordan 10
Nike Air Jordan 1
Nike Shoes 2019
Pandora Charm Bracelet
Air Jordans 1
Christian Louboutin Outlet
Air Max 2019
Pandora Jewelry
Adidas Sneakers
Lebron Shoes
Nike Huarache Men
Asics Shoes Outlet
Nike Black Friday Sales
Jordan Retro 13
Nike Outlet Store
UNC Jordan 1
Pandora Jewelry
Air Jordan Shoes
Red Bottom Shoes For Women
Womens Nike Shoes
Christian Louboutin
Pandora Sale
Cheap Nikes
Nike Zoom
Nike Store
Pandora
Air Max 720
Jordan Shoes
Nike KD
Nike Shoes For Men
Jordan 1s
Nike Shoes For Kids
Nike Shoes
Yeezy 500 Blush
Nike Factory Outlet Store Online
Nike Air Max 720
Jordan retro 14
Lebron 16
Adidas Ultra Boost
Cheap Yeezy
Air Force 1 Low
Jordan Sneakers
Nike Kyrie
Nike Running Shoes For Men
Air Jordans
Jordan 11
Golden Goose Shoes
Louboutin
New Nike Shoes 2019
Pandora Bracelets
Pandora Jewelry Official Site
Christian Louboutin shoes
Air Jordan 3
Jordan Kids
Nike Store Online
Jordan 9
Nike Sneaker
Pandora Jewelry
Nike Clearance Store
ggaoiuaqw870
文章: 1509
註冊時間: 2022年 8月 25日, 09:08

2022年 9月 30日, 13:46

Nike Website
Air Jordan 11
Louboutin Shoes
Hermes Birkin
Asics Running Shoes
Jordan 1
Huaraches Nike
Pandora
Nike Air Jordan 1s
Pandora Charms
Moncler Coats
Air Jordan 6
Golden Goose Sneakers Outlet
Nike Air Max 98
Red Bottom
GGDB
Air Jordan Sneakers
Nike Shoes
Air Jordan 4
Fjallraven Kanken
New Jordans 2018
Red Bottoms Louboutin
Air Jordan
Air Jordan Retro 14
Balenciaga Sneakers
Jordan 1 Low
Jordan 1 Mid
Yeezy
Jordan 10
Air Max 2018
Air Max
Air Jordan
Jordans Retro
Golden Goose Shoes
Jordan 11
Jordans 1s
Pandora
Nike Snkrs
Jordan 5
Soccer Shoes
Cheap Nike Shoes
Adidas NMD
Jordan 6 Retro
Moncler Jackets
Nike Jordans
Moncler Jacket
Air Jordan 4
NMD R1
Air Jordan 3 Retro
Jordan 12
Air Jordan Sneakers
Pandora
Air Force Ones Shoes
Jordan 11s
Jordan 5
Jordan 5s
Nike Shoes Outlet
Yeezy Sneakers
Air Jordans
Kyrie Irving Shoes
Golden Goose Mid Stars
Jordan 6 Rings
Nike Factory Outlet
Pandora Ring
Air Jordan Retro 12
Vans
Air Max 270
Jordan 4
Golden Goose
Jordan 12
Moncler Jackets For Men
Pandora Rings Official Site
Air Jordan 9
Fitflop Shoes
New Jordans
Jordan 11 Red
ECCO
Jordans Retro
Jordan Shoes For Men
Air Jordan 11
Nike Outlet
Pandora Jewelry
Nike Jordan 1
Yeezys
Yeezys
Jordan Retro 12
Nike For Women
Golden Goose Outlet
Golden Gooses Sneakers Sale
Pandora Bracelet Charms
Pandoras Jewelry
Jordan 3s
Jordan 8
Christian Louboutin UK
Jordans 11
Air Jordans
Jordan Retro 11 Mens
Adidas Yeezy
Yeezys
Pandora Jewelry
Mens Nike Shoes
Nike Outlet
Jordan 4 Retro
Pandora Jewelry
Air Max 90
Cheap Air Max
Moncler Vest
GGDB Sneakers
Jordans Shoes
Jordan Retro 1
Jordan 12
Golden Goose Sneakers
Harden Shoes
Christian Louboutin
Jordan 1
Jordan Retro
Louboutin shoes
Pandora Charms
Jordans Sneakers
Air Jordan 11
Jordan 13
Jordans Sneakers
GGDB Shoes
Nike Air Max 270
Lebron James Shoes
Ferragamo Outlet
Air Jordan Sneakers
Christian Louboutin Shoes
Cheap Jordans For Sale
Valentino Sandals
Nike Outlet Store Online Shopping
Jordan Shoes For Women
Golden Goose Sale
Yeezys
Golden Goose Sneakers Sale
Nike Shoes
Air Max 95
Jackets Moncler
Christian Louboutin Heels
Air Jordan 4 Retro
Nike Factory Store
Red Bottoms Louboutin
Air Jordan 6
Nike Sale
Triple S Balenciaga
Jordan 13s
Nike Outlet
Jordan 1
Jordan 11
Jordan Retros
Retro Jordans
Jordan 11's
Nike Outlet Store Online
Jordan Shoes For Men
ggaoiuaqw870
文章: 1509
註冊時間: 2022年 8月 25日, 09:08

2022年 10月 24日, 16:06

Lebron 16
Ultraboost
Christian Louboutin Outlet
Mens Nike Shoes
Nike Air Jordan
Nike Cortez
Nike Clearance Outlet
Lebron 16
Nike Outlet Store
Nike Jordans
Nike Hyperadap
Golden Goose Shoes
Nike Outlet Store
Christian Louboutin Shoes
Ferragamo
Jordan 11
Nike Factory
Kyrie Shoes
Nike Clearance Store
Pandora Bracelet Charms
Yeezy
Nike Outlet Store Online
Nike Air Huarache
Nike Clearance Outlet
Air Jordan 8
Asics Shoes Outlet
Jordan Retro
Pandora
Yeezys Shoes
Lebron Shoes 2019
Nike Shoes For Men Basketball
Nike Outlet Online
Jordan Shoes For Men
Nike Air Zoom Pegasus
Mens Nike Shoes
Red Bottoms
Nike Zoom Pegasus 35
Nike Air Max 97
Nike Free
Air Jordan 3
Nike Outlet Store
Nike Jordan 1
Jordans Sneakers
Air Force 1 Mid
Nike Sneakers For Women
Louboutin Heels
Christian Louboutin Shoes
Air Jordan 13 Retro
Jordan 1 Retro High
Christian Louboutin Heels
Yeezy Boost 750
Kevin Durant Shoes
NMD R1
Louboutin Shoes
Nike Store
Pandora Jewelry Official site
Air Jordan 7
Nike Shox For Women
Pandora Jewelry
Pandora
Adidas Yeezys
Nike Air Presto
Jordan Retro
Louboutin Shoes
Nike Factory Outlet
Valentino Shoes
New Nike Shoes 2019
Fjallraven Kanken
Nike Sneakers For Men
Nike Running Shoes For Women
Pandora Canada
Nike Shoes
Jordan 4's
Nike Shoes
Kyrie Irving Sneakers
Nike Free Run
NMD Adidas
Jordan 1 UNC
Jordan 13 Retro
Pandora Earrings
Red Bottom Shoes
Kids Nike Shoes
Yeezy Shoes
Nike Clearance
Air Max 720
Nike Air Force One
Christian Louboutin
New Nike Shoes 2019
Christian Louboutin
Jordan 1 Mids
Basketball Shoes Nike
Nike Factory Store
Yeezy
Jordans 1
Fjallraven Kanken Backpack
Adidas Sneakers For Women
Cheap Nikes
Pandora Canada
Nike Outlet Store
Air Jordan 11 Retro
Louboutin Outlet
Jordan Retro 11
Jordan 14
Nike Store
Pandora Ring
Yeezy 500 Black
Michael Jordan Shoes
Yeezys Boost 350 V2
Lebron James Shoes
Jordan 12's
Air Max 95
Air Max 2019
Jordan 11 Blue
Ferragamo
Pandora Bracelets And Charms
Nike Shoes For Men
Jordan 9
Nike Outlet
Air Max 98
Vans Shoes Outlet
Jordan Kids
Air Force Ones
Nike Epic React
Jordan AJ 1 Mid
New Nike Shoes
Nike Outlet Store Online Shopping
Nike Air Max 270 Men
Nike Clearance
Nike Outlet Store Online Shopping
Nike Running Shoes For Men
Nike Running Shoes
Nike Air Max 98
Pandora Outlet
Nike Sneakers
Pandora Charm
Pandora Charms
Air Jordan 4 Retro
Pandora Bracelet
Nike Black Friday 2020
Nike Air Force 1
Jordan Retro 10
Air Jordan Shoes
Air Jordans
Nike Air Max
Pandora Charms Jewelry
Nike Outlet Store
Pandora Jewelry Official Site
Jordan 1s
Nike Sneaker
Pandora
Christian Louboutin shoes
Nike 720
Pandora Necklace For Women
Pandora
New Jordans Coming Out
Moncler Outlet UK
Adidas Ultra Boost Women
Nike Store Online
Jordan 32
回覆文章